Victoria Casasco was born in Buenos Aires, Argentina to a Chicago native and an Italian national. As a child she lived in Argentina, the United States and Brazil. She received a Bachelor of Fine Arts Degree in Sculpture from the Rhode Island School of Design in 1978. During this period she received awards in sculpture and exhibited her work in New York City, at P.S.1, and in Rome, at the Palazzo Cenci.

At the age of twenty one, and after almost fifteen years of her engagement with sculpture, Casasco sought a discipline that would give her more engagement with civic life. She enrolled at Columbia University Graduate School of Architecture and Planning where she received her Masters of Architecture degree in 1983. During this time she worked with Duany Plater-Zyberk Architects on the Town of Seaside and with environmental artist Alan Sonfist on the Texas landscape. After receiving her Masters degree she worked as a designer in the office of Robert A.M.Stern Architects from 1983 to 1985.

In 1985 Victoria left New York City for Barcelona, Spain. In Barcelona, she worked with Mila Correa Architects and also researched the work of 20th century Catalan architects. The result of this research was a feature on the work of MzLapena-Torres, published in Progressive Architecture in February 1987. In 1986, she established a partnership with Carlos Garcia Delgado, her collaborator on the design of the Aznar Residence in Barcelona. Upon returning to America in 1987, Casasco acted as Town Architect for Seaside, Florida. In 1987 she established CASASCOstudio.

Victoria Casasco's work has been included in numerous exhibitions and received several awards. She received the prestigious 40 Under 40 award for excellence in design. Her work was exhibited at The New York Architectural League after having received The Young Architects Award in 1993. The firm's work has also been exhibited in AIA shows at UCLA and the Pacific Design Center, and profiled at the Armory Center for the Arts, Los Angeles International Art Fair, University of Redlands, and the Milan Triennale of 1991.

Victoria Casasco has been teaching architecture for the last 15 years. Since 1999, she has been an Assistant Professor at Yale University, after teaching at Southern California Institute of Architecture in Los Angeles since 1990. She was a Visiting Professor at University of California in Los Angeles in 1996, Arizona State University in 1994 and at the University of Texas at Austin in 1992. From 1988 to 1990, she was an Assistant Professor at California State Polytechnic University in Pomona and from 1987 to 1988 she ran the Small Town Graduate Program Studio at Mississippi State University.

The firm’s work has been published internationally in both books and periodicals. Recent books which include an overview of the firm's projects are Architecture after Modernism (Thames and Hudson), From the Center (Monacelli Press), 40 Under 40 (Vitae Press), Casas International (Kliczkowski Press), Experimental Architecture in Los Angeles (Rizzoli International), Outdoor Rooms (Rockport Pub.) Amazing Space (Schiffer Pub.) and her work with the Town of Seaside in Seaside (Princeton Press). Selected projects have been published in L'Arca, Casa Vogue (Espana), Architecktur &Wohnen, Architectural Record, l'indusria italiana del Cemento, House Beautiful, Metropolitan Home, Interiors Magazine, and Architecture.

Casasco’s ongoing research in planning within her practice and in her teaching group planning studios, has been published in Square (San Francisco Press) and From the Edge (Southern California Institute of Architecture publication).